反应详情

2,3,5,6-Tetrahydropyran-4-one (5 g), benzyl mercaptan (6.2 g), nitromethane (2.7 cm3), and piperidine (1 cm3) were dissolved in benzene (50 cm3), and the mixture heated under reflux with azeotropic removal of water. After 8 days the reaction mixture was allowed to cool and washed first with dilute hydrochloric acid, then with water. The remaining solution was dried and the solvent then removed under reduced pressure to give the nitro system (8g, 60%). This material was sufficiently pure to be used without further purification.

1. temperaturethe mixture heated
2. temperatureto cool
3. washwashed first with dilute hydrochloric acid
4. customThe remaining solution was dried
5. customthe solvent then removed under reduced pressure