反应详情

温度

0 °C

To a solution of diisopropylamine (0.46 mL) in THF (3 mL) at 0° C. was added 1.6M BuLi in hexane (2.01 mL). After stirring for 30 minutes at 0° C., 2.74 mL of this solution was added to a solution of methyl (2-trimethylsilyloxyphenyl)acetate from Step 1, (357 mg) in THF (5 mL) at 0° C. After 20 minutes, ethyl iodide (0.144 mL) was added and the mixture was stirred for 18 hours at r.t. Then, 2 mL of 1N HCl was added and the resulting mixture was stirred for 30 minutes, extracted with EtOAc, washed twice with brine, dried over MgSO4, filtered, and evaporated to dryness, giving the title compound.

1. waitAfter 20 minutes
2. stirringthe mixture was stirred for 18 hours at r.t
3. stirringthe resulting mixture was stirred for 30 minutes
4. extractionextracted with EtOAc
5. washwashed twice with brine
6. dry with materialdried over MgSO4
7. filtrationfiltered
8. customevaporated to dryness