Hydrochloric Acid → HCID 59376826, compound

HRID 1036161Notes

Reaction equation

HRID 1036161 reaction equation
[CH:1]([C:4]1[CH:5]=[CH:6][C:7]2[C:12]([NH:13][C:14]3[CH:15]=[C:16]([CH:21]=[CH:22][CH:23]=3)[C:17]([O:19]C)=[O:18])=[N:11][CH:10]=[N:9][C:8]=2[N:24]=1)([CH3:3])[CH3:2].O.[Li+].[OH-].Cl>C1COCC1>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]2[C:12]([NH:13][C:14]3[CH:15]=[C:16]([CH:21]=[CH:22][CH:23]=3)[C:17]([OH:19])=[O:18])=[N:11][CH:10]=[N:9][C:8]=2[N:24]=1)([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 59376777HCID 59376777, compound

Product 1

HCID 59376826HCID 59376826, compoundYield 149.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The product from Example 7A (1.0 g, 3.26 mmol) was dissolved in THF (12.0 mL) and water (12.0 mL) and LiOH (390 mg, 16.29 mmol) was added and the reaction was stirred at room temperature overnight. Reaction was neutralized with 1 N HCl and extracted with ethyl acetate. Dried over Na2SO4, filtered and concentrated to give the title compound (1.5 g).

Workup

  1. customReaction
  2. extractionextracted with ethyl acetate
  3. dry with materialDried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-2c581421881445cbb890ac07e7029639
Source dataset
uspto-grants-2013_10
Patent number
US08546405B2

Reaction notes

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