Iodine → HCID 56941186, compound

Temperature

40 °C

Under a nitrogen atmosphere, magnesium (280 mg, 11.5 mmol) was suspended in dehydrated THF (2 ml), iodine (45 mg, 0.18 mmol) was added, bromobenzene (390 μl, 3.70 mmol) was slowly added dropwise, and the suspension was stirred at 40° C. for 4 hr. To the reaction mixture was added the aforementioned 2-(3′,7′,11′-trimethyldodecyloxy)-9-fluorenone (300 mg, 0.74 mmol), and the mixture was stirred at 50° C. overnight. The reaction mixture was cooled to room temperature, and the reaction was quenched with 1N hydrochloric acid (30 ml). The mixture was extracted with chloroform (40 ml), and the extract was washed three times with 1N hydrochloric acid (20 ml), three times with 5% aqueous sodium hydrogen carbonate solution (20 ml), and once with 20% brine (20 ml). The solvent of the organic layer was evaporated, and the obtained residue was purified and separated by silica gel column chromatography (hexane:ethyl acetate=10:1) to give 2-(3′,7′,11′-trimethyldodecyloxy)-9-phenylfluoren-9-ol (181 mg, 0.37 mmol, yield 51%).

1. stirringthe mixture was stirred at 50° C. overnight
2. temperatureThe reaction mixture was cooled to room temperature
3. customthe reaction was quenched with 1N hydrochloric acid (30 ml)
4. extractionThe mixture was extracted with chloroform (40 ml)
5. washthe extract was washed three times with 1N hydrochloric acid (20 ml), three times with 5% aqueous sodium hydrogen carbonate solution (20 ml)
6. customThe solvent of the organic layer was evaporated
7. customthe obtained residue was purified
8. customseparated by silica gel column chromatography (hexane:ethyl acetate=10:1)

ORD record

ord-dcfa5db45396453994bda3cf5f5c123f

Source dataset

uspto-grants-2013_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08546534B2