Triethylamine → HCID 86630177, compound

HRID 1038114Notes

Reaction equation

HRID 1038114 reaction equation
[CH:1]1([C:4]2[CH:9]=[C:8]([C:10]3[C:18]4[C:13](=[CH:14][CH:15]=[C:16]([NH:19][C:20]([C:22]5([CH2:27][O:28][CH3:29])[CH2:26][CH2:25][NH:24][CH2:23]5)=[O:21])[CH:17]=4)[NH:12][N:11]=3)[CH:7]=[CH:6][N:5]=2)[CH2:3][CH2:2]1.Cl[CH2:31][C:32]([N:34]1[CH2:39][CH:38]=[C:37]([C:40]2[CH:45]=[CH:44][C:43]([C:46]3[N:51]=[CH:50][C:49]([F:52])=[CH:48][N:47]=3)=[C:42]([F:53])[CH:41]=2)[CH2:36][CH2:35]1)=[O:33].C(N(CC)CC)C>CN(C)C=O>[CH:1]1([C:4]2[CH:9]=[C:8]([C:10]3[C:18]4[C:13](=[CH:14][CH:15]=[C:16]([NH:19][C:20]([C:22]5([CH2:27][O:28][CH3:29])[CH2:26][CH2:25][N:24]([CH2:31][C:32]([N:34]6[CH2:35][CH:36]=[C:37]([C:40]7[CH:45]=[CH:44][C:43]([C:46]8[N:47]=[CH:48][C:49]([F:52])=[CH:50][N:51]=8)=[C:42]([F:53])[CH:41]=7)[CH2:38][CH2:39]6)=[O:33])[CH2:23]5)=[O:21])[CH:17]=4)[NH:12][N:11]=3)[CH:7]=[CH:6][N:5]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 57686028HCID 57686028, compoundHCID 86630178HCID 86630178, compound

Product 1

HCID 86630177HCID 86630177, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3-Methoxymethyl-pyrrolidine-3-carboxylic acid [3-(2-cyclopropyl-pyridin-4-yl)-1H-indazol-5-yl]-amide (26AB) (85 mg, 0.217 mmol, 1 equiv) and 2-Chloro-1-{4-[3-fluoro-4-(5-fluoro-pyrimidin-2-yl)-phenyl]-3,6-dihydro-2H-pyridin-1-yl}-ethanone (23AB) (84 mg, 0.239 mmol, 1.1 equiv) were weighed out in a flask and dissolved in anhydrous N,N-dimethylformamide (5 mL). Triethyl amine (33 mg, 46 uL, 0.326 mmol, 1.5 equiv) was added to the reaction mixture and the reaction content was stirred at room temperature overnight.

Sources & evidence

ORD record
ord-199f5d0e518049cb95cd904b470d3e6c
Source dataset
uspto-grants-2013_10
Patent number
US08546404B2

Reaction notes

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