Hydrogen Bromide → 5-bromo-2-(2,5-dichloro-pyrimidin-4-ylamino)-3-fluoro-N-methyl-benzamide
Reaction equation
[NH2:1][C:2]1[C:11]([F:12])=[CH:10][C:9]([Br:13])=[CH:8][C:3]=1[C:4]([NH:6][CH3:7])=[O:5].Br.CN1CCCC1=O.C(N(CC)C(C)C)(C)C.[Cl:31][C:32]1[N:37]=[C:36](Cl)[C:35]([Cl:39])=[CH:34][N:33]=1>>[Br:13][C:9]1[CH:10]=[C:11]([F:12])[C:2]([NH:1][C:34]2[C:35]([Cl:39])=[CH:36][N:37]=[C:32]([Cl:31])[N:33]=2)=[C:3]([CH:8]=1)[C:4]([NH:6][CH3:7])=[O:5]Participants
Conditions
- Temperature
- 100 °C
Procedure
2-Amino-5-bromo-3-fluoro-N-methyl-benzamide; hydrobromide (2.00 g, 6.10 mmol) was placed in N-methylpyrrolidinone (20.0 mL, 207 mmol) and N,N-diisopropylethylamine (3.19 mL, 18.3 mmol) was added. The reaction was stirred for 5 minutes and then 2,4,5-trichloro-pyrimidine (3.50 mL, 30.5 mmol) was added. The reaction was heated at 100° C. for 24 hours and then concentrated under reduced pressure. The residue was taken up in DCM (100 mL) and washed twice with water (100 mL). The organic layer was dried over sodium sulfate, filtered, and concentrated under reduced pressure. Purification by silica gel chromatography using a gradient of 0-40% EtOAc/hex as the eluting solvent to obtain 5-bromo-2-(2,5-dichloro-pyrimidin-4-ylamino)-3-fluoro-N-methyl-benzamide as a tan solid (1.19 g, 50%). m.p.=246-249° C.; LCMS (m/e) 393 (M+H); 1H-NMR (d6-DMSO, 400 MHz) δ 9.73 (s, 1H), 8.68-8.57 (m, 1H), 8.43 (s, 1H), 7.87 (d, 1H, J=9.6 Hz), 7.66 (s, 1H), 2.69 (d, 3H, J=3.9 Hz); 19F-NMR (d6-DMSO, 400 MHz) δ −113.
Workup
- concentrationconcentrated under reduced pressure
- washwashed twice with water (100 mL)
- dry with materialThe organic layer was dried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated under reduced pressure
- customPurification by silica gel chromatography
Sources & evidence
- ORD record
- ord-bf7e9e95077043bbbb40909bd6e08e85
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08552186B2
Reaction notes
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