反应详情

温度

90 °C

To a solution of 5-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carbothioamide (1.4 g) in tetrahydrofuran (10 mL) and toluene (15 mL) were added ethyl 2-butynoate (0.88 g) and tri-n-butylphosphine (0.63 g), and the mixture was stirred at 90° C. for 1 hr. The reaction mixture was cooled, and concentrated under reduced pressure. The obtained crude product was subjected to silica gel column chromatography (ethyl acetate:hexane=0:100 to 100:0, volume ratio) to give the title compound (1.05 g, yield 60%) as a yellow amorphous solid.

1. temperatureThe reaction mixture was cooled
2. concentrationconcentrated under reduced pressure
3. customThe obtained crude product