Hydrogen Bromide → HCID 44218047, compound

HRID 1042365Notes

Reaction equation

HRID 1042365 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:32])/[CH:10]=[CH:11]/[C:12]1[CH:16]=[CH:15][N:14]([S:17]([C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:27]=[N:28][N:29]([CH3:31])[CH:30]=3)=[CH:22][CH:21]=2)(=[O:19])=[O:18])[CH:13]=1.[BrH:33]>C1COCC1>[BrH:33].[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:32])/[CH:10]=[CH:11]/[C:12]1[CH:16]=[CH:15][N:14]([S:17]([C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:27]=[N:28][N:29]([CH3:31])[CH:30]=3)=[CH:22][CH:21]=2)(=[O:19])=[O:18])[CH:13]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 159859044SC-202 (free base)

Product 1

HCID 44218047HCID 44218047, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To 0.21 g of (E)-N-(2-amino-phenyl)-3-{1-[4-(1-methyl-1H-pyrazol-4-yl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acrylamide in 4 ml THF a solution of 0.169 ml of 48%-HBr (169 μL, 1.5 mmol) in 4 ml THF was added dropwise. A solid separated, which was treated with diethylether. The resulting crystalline solid was separated and dried overnight. Yield: 287 mg (100%); MP: 200° C., sinter. The compound contained 1.86 HBr/Mol.

Workup

  1. customA solid separated
  2. additionwhich was treated with diethylether
  3. customThe resulting crystalline solid was separated
  4. customdried overnight

Sources & evidence

ORD record
ord-59df0c89144c4d23bda1324e2d824cf6
Source dataset
uspto-grants-2013_10
Patent number
US08557858B2

Reaction notes

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