反应详情

温度

65 °C

2-Methyl-3-nitrobenzylchloride (1.0 g, 5.4 mmol) was dissolved in 30 ml of THF, and to this was added 1-methyl-piperazine (0.65 g, 6.5 mmol) and sodium bicarbonate (2.26 g, 26.9 mmol). The reaction mixture was stirred at 65° C. for 16 hours. The mixture was partitioned between EtOAc and H2O. The aqueous layer was extracted with EtOAc, and the combined organic layers were washed with saturated NH4Cl, H2O, brine and dried over MgSO4. Solvent evaporation afforded 1-(2-methyl-3-nitrobenzyl)-4-methylpiperazine.

1. customThe mixture was partitioned between EtOAc and H2O
2. extractionThe aqueous layer was extracted with EtOAc
3. washthe combined organic layers were washed with saturated NH4Cl, H2O, brine
4. dry with materialdried over MgSO4
5. customSolvent evaporation