Hydrochloric Acid → HCID 178500867, compound

HRID 1045867Notes

Reaction equation

HRID 1045867 reaction equation
[CH3:1][O:2][C:3](=[O:7])[CH2:4][C:5]#[N:6].[OH:8][NH2:9].Cl>C1COCC1>[CH3:1][O:2][C:3](=[O:7])[CH2:4][C:5](=[NH:6])[NH:9][OH:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 787HydroxylamineHCID 7747Methyl cyanoacetate

Product 1

HCID 178500867HCID 178500867, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
80 °C

Procedure

2-Cyano-acetic acid methyl ester (990 mg, 10 mmol) was dissolved in THF (30 mL). Hydroxy amine (690 mg, HCl salt, 10 mmol) was added thereto, and the mixture was stirred for 2 h at 80° C. After completion of the reaction, 1N HCl was added. The reaction mixture was extracted with EtOAc, and dried over MgSO4. The solvent was removed under reduced pressure, and the residue was used in the next reaction without further purification.

Workup

  1. additionwas added
  2. extractionThe reaction mixture was extracted with EtOAc
  3. dry with materialdried over MgSO4
  4. customThe solvent was removed under reduced pressure
  5. customthe residue was used in the next reaction without further purification

Sources & evidence

ORD record
ord-9a867bf494ad4302ae559000c754ff3d
Source dataset
uspto-grants-2013_10
Patent number
US08569307B2

Reaction notes

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