反应详情

温度

110 °C

A mixture of 3-amino-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylic acid methyl ester (0.200 g, 0.843 mmol), palladium acetate (0.019 g, 0.084 mmol), xantphos (0.058 g, 0.101 mmol), cesium carbonate (0.767 g, 2.36 mmol) and 2-(4-Bromo-phenoxy)-pyridine (0.252 g, 1.01 mmol) in toluene (3 mL) was heated by microwave to 110° C. for 45 minutes. The reaction was diluted with ethyl acetate filtered through a Celite pad and purified by silica gel chromatography to give 5-(3,3-Dimethyl-but-1-ynyl)-3-[4-(pyridin-2-yloxy)-phenylamino]-thiophene-2-carboxylic acid methyl ester in 66% yield.

1. filtrationfiltered through a Celite pad
2. custompurified by silica gel chromatography