Hydrochloric Acid → HCID 14435731, compound

HRID 1047354Notes

Reaction equation

C1(N2CC[O:10]CC2)CCCCC=1.C(N(CC)CC)C.[C:20](Cl)(=[O:25])[CH2:21][CH:22]([CH3:24])[CH3:23].Cl.[C:28]1(C)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[CH3:23][CH:22]([CH3:24])[CH2:21][C:20]([CH:29]1[CH2:30][CH2:31][CH2:32][CH2:33][C:28]1=[O:10])=[O:25]

Participants

Reactant 5

HCID 313Hydrochloric Acid

HCID 1140Toluene

HCID 8471Triethylamine

HCID 66054Isovaleryl chloride

HCID 69589Morpholine, 4-(1-cyclohexen-1-yl)-

Product 1

HCID 14435731HCID 14435731, compoundYield 90%

Procedure

Compound IVd is obtained in 90% yield as a pale yellow liquid, according to Example 4, from 4-cyclohex-1-enyl-morpholine (82.64 g, 0.5 mol, obtained in Example 1), triethylamine (71.34 g, 0.71 mol), isovaleryl chloride (85.01 g, 0.71 mol), toluene (760 mL) and 20% aqueous HCl (166 mL).

Workup

customCompound IVd is obtained in 90% yield as a pale yellow liquid

Sources & evidence

ORD record: ord-8da7be3a70904bd09b519bf4ec836425
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08569518B2

Reaction notes

Loading…