反应详情

温度

80 °C

2-Hydroxy-9-fluorenone (196 mg, 2.04 mmol) was dissolved in DMF (8 ml), potassium carbonate (423 mg, 3.06 mmol), and docosyl bromide (96%, 785 mg, 1.93 mmol) were added. The mixture was heated to 80° C. and stirred overnight. After completion of the reaction, the reaction mixture was cooled to room temperature, and 1N hydrochloric acid (4 ml) was added dropwise thereto in a water bath to quench the reaction. The mixture was extracted with chloroform (23 ml), and washed once with 1N hydrochloric acid (7.5 ml) and 4 times with pure water (7.5 ml). The solvent of the organic layer was evaporated, and the residue was precipitated with methanol (10 ml) to give 2-docosyloxy-9-fluorenone (934 mg, 1.85 mmol, 96%).

1. customAfter completion of the reaction
2. temperaturethe reaction mixture was cooled to room temperature
3. customin a water bath to quench
4. customthe reaction
5. extractionThe mixture was extracted with chloroform (23 ml)
6. washwashed once with 1N hydrochloric acid (7.5 ml) and 4 times with pure water (7.5 ml)
7. customThe solvent of the organic layer was evaporated
8. customthe residue was precipitated with methanol (10 ml)