Trichloroisocyanuric Acid → 4-((Tert-butoxy)carbonyl)morpholine-2-carboxylic acid

Saturated aqueous NaHCO3 (15 mL) was added to a stirred solution of tert-butyl 2-(hydroxymethyl)morpholine-4-carboxylate (1.09 g, 5.0 mmol) (heterocycles, (1993), 35, 105 and WO 2007/06715) in acetone (50 mL) at 0° C. Solid NaBr (0.1 g, 1 mmol) and TEMPO (0.015 g, 0.1 mmol) were added. trichloroisocyanuric acid (2.32 g, 10.0 mmol) was then added for 20 min at 0° C. After addition the reaction mixture was allowed to rise to RT and stirred overnight. 2-Propanol (3 mL) was added and the resulting solution was stirred at RT for 30 min, filtered through a pad of Celite, concentrated under vacuum, and treated with saturated aqueous Na2CO3 solution (15 mL) The aqueous solution was extracted with EtOAc (5 mL), acidified with 6N HCl and extracted with EtOAc (5×10 mL). The combined organic layers were dried over Na2SO4 and the solvent was concentrated to give the title compound as a white solid (1.1 g crude) (M−H) 230.

1. additionAfter addition the reaction mixture
2. customto rise to RT
3. stirringthe resulting solution was stirred at RT for 30 min
4. filtrationfiltered through a pad of Celite
5. concentrationconcentrated under vacuum
6. additiontreated with saturated aqueous Na2CO3 solution (15 mL) The aqueous solution
7. extractionwas extracted with EtOAc (5 mL)
8. extractionextracted with EtOAc (5×10 mL)
9. dry with materialThe combined organic layers were dried over Na2SO4
10. concentrationthe solvent was concentrated

ORD record

ord-c18684bd912d422ab6be159c239b0396

Source dataset

uspto-grants-2016_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09382216B2