反应详情

Cyclohexylacetyl chloride (1 mL, 6.52 mmol) was added to solution of NH4OH (˜15M, 5 mL, ˜75 mmol) in EtOAc (5 mL) and satd. NaHCO3 (5 mL) and stirred at RT for 20 minutes. The layers were separated, the aqueous layer extracted with EtOAc (2×) and the combined organics were dried over Na2SO4 and concentrated to dryness to afford 2-cyclohexylacetamide (481 mg, 52%) as a white solid.

1. customThe layers were separated
2. extractionthe aqueous layer extracted with EtOAc (2×)
3. dry with materialthe combined organics were dried over Na2SO4
4. concentrationconcentrated to dryness