Hydrochloric Acid → HCID 117760095, compound

HRID 1049582Notes

Reaction equation

HRID 1049582 reaction equation
C(=O)([O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:15]=2[F:22])=[C:10]([CH2:23][CH2:24][C:25]([O:28][CH3:29])([CH3:27])[CH3:26])[CH:9]=1)OC(C)(C)C.Cl>C(OCC)(=O)C>[F:22][C:15]1[CH:16]=[CH:17][C:18]([O:20][CH3:21])=[CH:19][C:14]=1[C:11]1[CH:12]=[CH:13][C:8]([OH:7])=[CH:9][C:10]=1[CH2:23][CH2:24][C:25]([O:28][CH3:29])([CH3:27])[CH3:26]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 117760106HCID 117760106, compound

Product 1

HCID 117760095HCID 117760095, compoundYield 134.1%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of tert-butyl 2′-fluoro-5′-methoxy-2-(3-methoxy-3-methylbutyl)biphenyl-4-yl carbonate (199 mg) in ethyl acetate (5 mL) was added a solution (4 M, 2 mL) of hydrogen chloride in ethyl acetate, and the mixture was stirred at room temperature for 20 hr. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (203 mg) as a colorless oil.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

Sources & evidence

ORD record
ord-4a18fad81b5b47feb5dcdf2946da3883
Source dataset
uspto-grants-2016_07
Patent number
US09382188B2

Reaction notes

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