反应详情

To a solution of tert-butyl 2′-fluoro-5′-methoxy-2-(3-methoxy-3-methylbutyl)biphenyl-4-yl carbonate (199 mg) in ethyl acetate (5 mL) was added a solution (4 M, 2 mL) of hydrogen chloride in ethyl acetate, and the mixture was stirred at room temperature for 20 hr. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (203 mg) as a colorless oil.

1. customThe solvent was evaporated under reduced pressure
2. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)