Hydrochloric Acid → L-Alanine, phenylmethyl ester, hydrochloride (1:1)

HRID 1050913노트

반응식

HRID 1050913 반응식
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:4]([O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:5])[CH3:3].N#N.[ClH:23]>O1CCOCC1>[NH2:1][C@H:2]([C:4]([O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:5])[CH3:3].[ClH:23]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 947NitrogenHCID 10972741BOC-L-Alanine benzyl ester

생성물 1

HCID 12210893L-Alanine, phenylmethyl ester, hydrochloride (1:1)

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Boc-Ala-OBn was dissolved in 4N HCl in dioxane (10 mL) and stirred for three hours at room temperature. The solvent was blown off under a stream of N2. The residue was placed under high vacuum for one hour. Re-dissolved in CH2Cl2 (50 mL) and rotovap dry. Repeat the drying circle for three times till the white powder forms.

후처리

  1. waitThe residue was placed under high vacuum for one hour
  2. dry with materialRe-dissolved in CH2Cl2 (50 mL) and rotovap dry

출처 및 근거

ORD 기록
ord-f1310d1d63a64cd29851716705ffebc6
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09388132B2

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