反应详情

温度

75 °C

4-Bromo-5-fluoropyrimidine (5 g) was reacted with potassium vinyltrifluorborate (1.05 equivalents) in the presence of (PPh3)2PdCl2 (0.02 eq), PPh3 (0.02 eq), and Cs2CO3 (3 equivalents) in a mixture of methyl tetrahydrofuran (85 ml) and water (8.5 ml). The reaction was heated at 75° C. for about 5.5 hours. The reaction mixture was then diluted with methyl tert-butyl ether (50 ml), followed by aqueous extraction. The crude product was purified by distillation at 170 mbar (90-110° C.). The product was obtained as a colourless oil (1.44 g, 41% yield).

1. extractionfollowed by aqueous extraction
2. distillationThe crude product was purified by distillation at 170 mbar (90-110° C.)