2-Aminothiazole → HCID 67028283, compound

HRID 1051320Notes

Reaction equation

HRID 1051320 reaction equation
Br[CH:2]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:3]([C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1)=O.[NH2:21][C:22]1[S:23][CH:24]=[CH:25][N:26]=1>CN(C=O)C>[C:15]1([C:2]2[N:26]3[C:22]([S:23][CH:24]=[CH:25]3)=[N:21][C:3]=2[C:5]2[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 21552-AminothiazoleHCID 86631776HCID 86631776, compound

Product 1

HCID 67028283HCID 67028283, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.7 g (2.1 mM) of methyl 4-[bromo(phenyl)acetyl]benzoate and 2-aminothiazole (2.5 eq) are stirred in 20 ml DMF at 90° C. for 6 h. The DMF is evaporated and the crude product is purified by column chromatography.

Workup

  1. customThe DMF is evaporated
  2. customthe crude product is purified by column chromatography

Sources & evidence

ORD record
ord-f112a5bb52c344d5aaa0b05aa991d7c2
Source dataset
uspto-grants-2016_07
Patent number
US09387204B2

Reaction notes

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