2-Aminothiazole → 4-Imidazo[2,1-b]thiazol-6-ylbenzaldehyde

HRID 1051330Notes

Reaction equation

HRID 1051330 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][CH:6]=1)=O.[NH2:13][C:14]1[S:15][CH:16]=[CH:17][N:18]=1>CN(C=O)C>[S:15]1[CH:16]=[CH:17][N:18]2[CH:2]=[C:3]([C:5]3[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][CH:6]=3)[N:13]=[C:14]12

Participants

4

Reactant 2

HCID 21552-AminothiazoleHCID 17755522HCID 17755522, compound

Product 1

HCID 3982844-Imidazo[2,1-b]thiazol-6-ylbenzaldehyde

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.7 g (2.1 mM) 4-(2-Bromo-acetyl)-benzaldehyde and 2-aminothiazole (2 eq) are stirred in 15 ml DMF at 90° C. for 6 h. The DMF is evaporated and the residue suspended in ethyl acetate over night. The desired product is collected by filtration.

Workup

  1. customThe DMF is evaporated
  2. waitthe residue suspended in ethyl acetate over night
  3. filtrationThe desired product is collected by filtration

Sources & evidence

ORD record
ord-5c5d00645c854e0ba2dc2b3cc74c1f9d
Source dataset
uspto-grants-2016_07
Patent number
US09387204B2

Reaction notes

Loading…