反应详情

1.8 gms of Sodium hydride was taken in 50 ml of tetrahydrofuran at 0° C., to this 5 gms of 1-(4-Fluoro-phenyl)-5-hydroxy-5-morpholin-4-yl-pentan-1-one was added under nitrogen atmosphere and maintained for about 30 minutes. To the reaction mass 3.4 gms of benzyl bromide was added at 20-25° C. and stirred for about 6 hours. Quenched the reaction mass with hydrochloric acid and stirred for about 15 minutes. Separated the layers and extracted the reaction mass with ethyl acetate. Organic layer was separated and dried over sodium sulphate. Distilled off the solvent completely and isolated the compound by adding 7 ml of toluene and 35 ml of hexane. Filtered the compound, washed with hexane and dried at 35-40° C. to get 5.6 gms of 5-Benzyloxy-5-(4-fluoro-phenyl)-1-morpholin-4-yl-pentan-1-one.

1. additionwas added under nitrogen atmosphere
2. temperaturemaintained for about 30 minutes
3. customQuenched the reaction mass with hydrochloric acid
4. stirringstirred for about 15 minutes
5. customSeparated the layers
6. extractionextracted the reaction mass with ethyl acetate
7. customOrganic layer was separated
8. dry with materialdried over sodium sulphate
9. distillationDistilled off the solvent completely
10. customisolated the compound
11. filtrationFiltered the compound
12. washwashed with hexane
13. customdried at 35-40° C.