反应详情

Next, a mixed solution of 17.7 g of 2-chloro-9H-carbazole, 22 g of iodobenzene, 20 g of a copper powder, 43 g of potassium carbonate and 200 ml of dimethylformamide was heated/stirred at 140° C. for 16 hours under a nitrogen flow. The solution was cooled to room temperature, 50 ml of ethyl acetate was added, and the mixture was filtered with Celite. To the resultant filtrate was added a saturated aqueous ammonium chloride solution, and the mixture was stirred for a while, and then extracted with ethyl acetate and hexane. The extract was dried over magnesium sulfate, and then evaporated. The concentrate was purified by silica gel column chromatography and vacuum-dried to obtain 14 g of 2-chloro-9-phenyl-9H-carbazole.

1. filtrationthe mixture was filtered with Celite
2. additionTo the resultant filtrate was added a saturated aqueous ammonium chloride solution
3. extractionextracted with ethyl acetate and hexane
4. dry with materialThe extract was dried over magnesium sulfate
5. customevaporated
6. customThe concentrate was purified by silica gel column chromatography
7. customvacuum-dried