反应详情

N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)formamide (1 g) taken in a mixture of tetrahydrofuran (10 ml) and sodium hydride (0.11 g) stirred reaction mass at 25 to 30° C. for 30 minutes. To this mixture added 5-chlorothiophene carbonyl chloride (0.86 g). Obtained reaction mass then stirred for 1 to 2 h at 25 to 30° C. After completion of reaction, added ethyl acetate and water. Separated organic layer and concentrated under reduced pressure to obtain residue. Added acetic acid and methanol to residue stirred for 30 minutes and obtained solid is filtered off. Washed solid with methanol

1. customreaction mass at 25 to 30° C. for 30 minutes
2. customObtained
3. customreaction mass
4. stirringthen stirred for 1 to 2 h at 25 to 30° C
5. customAfter completion of reaction
6. concentrationSeparated organic layer and concentrated under reduced pressure
7. customto obtain residue
8. customobtained solid
9. filtrationis filtered off
10. washWashed solid with methanol