反应详情

温度

0 °C

To a solution of oxetan-3-ylmethanol (1.00 g, 11.3 mmol) in DMF (10 mL) was added NaH (300 mg, 13.6 mmol) at 0° C. The mixture was then stirred at 0° C. for 10 min. 1-Bromo-4-fluorobenzene (2.30 g, 13.6 mmol) was added to the solution. The mixture was stirred at 90° C. for 2 h. The mixture was partitioned between water and EtOAc (30 mL×3). The combined organics was dried and concentrated to give the title compound (420 mg, 15% yield) as a yellow oil.

1. stirringThe mixture was stirred at 90° C. for 2 h
2. customThe mixture was partitioned between water and EtOAc (30 mL×3)
3. customThe combined organics was dried
4. concentrationconcentrated