Hydrochloric Acid → HCID 89980281, compound

HRID 1056562Notes

Reaction equation

HRID 1056562 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:16]([C:17]([C:19]4[C:20]([F:47])=[C:21]([N:26]([C:33](=[O:46])[C@@H:34]([NH:38]C(=O)OC(C)(C)C)[CH:35]([CH3:37])[CH3:36])[S:27]([CH2:30][CH2:31][CH3:32])(=[O:29])=[O:28])[CH:22]=[CH:23][C:24]=4[F:25])=[O:18])=[CH:15][NH:14][C:11]3=[N:12][CH:13]=2)=[CH:4][CH:3]=1.Cl>CCOC(C)=O>[ClH:1].[NH2:38][C@@H:34]([CH:35]([CH3:36])[CH3:37])[C:33]([N:26]([C:21]1[CH:22]=[CH:23][C:24]([F:25])=[C:19]([C:17]([C:16]2[C:10]3[C:11](=[N:12][CH:13]=[C:8]([C:5]4[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=4)[CH:9]=3)[NH:14][CH:15]=2)=[O:18])[C:20]=1[F:47])[S:27]([CH2:30][CH2:31][CH3:32])(=[O:28])=[O:29])=[O:46]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131736432HCID 131736432, compound

Product 1

HCID 89980281HCID 89980281, compoundYield 223.8%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of (S)-tert-butyl (1-(N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propylsulfonamido)-3-methyl-1-oxobutan-2-yl)carbamate (50 mg, 0.07 mmol) and a saturated solution of HCl in EtOAc (2 mL) was stirred at rt for 2 h. The mixture was concentrated in vacuo to afford the title compound as a white solid (49 mg, 99%). The title compound was characterized by LC-MS as shown below:

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-bd61aafcf9a147cc823c14e5e2decd5b
Source dataset
uspto-grants-2016_07
Patent number
US09399639B2

Reaction notes

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