Potassium Carbonate → HCID 18671325, compound

HRID 1057280Notes

Reaction equation

HRID 1057280 reaction equation
C(=O)([O-])[O-].[K+].[K+].Cl.[CH3:8][O:9][NH2:10].[C:11](Cl)(=[O:20])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]>C(OC(=O)C)C>[CH3:8][O:9][NH:10][C:11](=[O:20])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 69819Nonanoyl chlorideHCID 521874O-Methylhydroxylamine hydrochloride

Product 1

HCID 18671325HCID 18671325, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A 100 mL three-neck round-bottom flask equipped with a mechanical stirrer, argon inlet and pressure equalizing addition funnel is charged with ethylacetate (40 mL) and 1 M aqueous solution of potassium carbonate (20 mL, 2 eq). The reaction mixture is cooled in a salt water/ice bath. Methoxyamine hydrochloride (5.06 g, 1 eq) is added to the reaction mixture followed by a dropwise addition of nonanoyl chloride (10.58 g, 1 eq). The reaction stirs at room temperature overnight. The reaction is diluted with ethylacetate and separated from the aqueous. The organic layer is washed with deionized water (1×50 mL), dried over sodium sulfate, filtered, and concentrated under vacuum.

Workup

  1. customA 100 mL three-neck round-bottom flask equipped with a mechanical stirrer, argon inlet
  2. additionaddition funnel
  3. temperatureThe reaction mixture is cooled in a salt water/ice bath
  4. customseparated from the aqueous
  5. washThe organic layer is washed with deionized water (1×50 mL)
  6. dry with materialdried over sodium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-ecd1e74cd0cd45059dfcb58ea73a3644
Source dataset
uspto-grants-2003_02
Patent number
US06514925B1

Reaction notes

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