反应详情

温度

75 °C

Pyridinium bromide perbromide (0.7068 g, 0.0022 mol) is added to a mixture of 6-fluoro-9-(4-fluorobenzyl)-1,2,3,9-tetrahydro-4H-carbazol-4-one (0.5245 g, 0.0017 mol) in THF (4 mL) and DMF (4 mL) and the mixture is heated to 75° C. After stirring for 6.5 h, the mixture is stored in the freezer overnight. Heating is resumed for an additional 2.5 h, at which time THF is removed under reduced pressure and the residue is partitioned between dichloromethane and brine. The combined organic layers are washed with dilute sodium thiosulfate/brine and the aqueous layer is backwashed with dichloromethane. The combined organic layers are dried over sodium sulfate and concentrated under reduced pressure to give a residue. The residue is heated to 120° C. in DMF (8 mL) with lithium bromide (0.3412 g, 0.0039 mol) and lithium carbonate (0.2548 g, 0.0035 mol). After 2 h, DMF is removed under high vacuum and the mixture is partitioned between dichloromethane and water. The combined organic layers are washed with water, dried over sodium sulfate and concentrated to an oil. The oil is chromatographed on silica gel (100 mL) using dichloromethane/hexane (30/70 to 50/50) to give 0.2706 g (52%) of the title compound; MS (ESI−) for C19H13F2NO m/z 308.0 (M−H)−; IR (drift) 1511, 1483, 1465, 1450, 1336, 1222, 1215, 1172, 1157, 1138, 883, 858, 791, 777, 744 cm−1; 1H NMR (CDCl3) δ5.35, 5.44, 6.57, 6.95, 7.06-7.30, 8.01. Anal. Calcd for C19H13F2NO: C, 73.78; H, 4.24; N, 4.53. Found: C, 72.65; H, 4.20; N, 4.45.

1. customis stored in the freezer overnight
2. temperatureHeating
3. customis removed under reduced pressure
4. customthe residue is partitioned between dichloromethane and brine
5. washThe combined organic layers are washed with dilute sodium thiosulfate/brine
6. dry with materialThe combined organic layers are dried over sodium sulfate
7. concentrationconcentrated under reduced pressure
8. customto give a residue
9. waitAfter 2 h
10. customDMF is removed under high vacuum
11. customthe mixture is partitioned between dichloromethane and water
12. washThe combined organic layers are washed with water
13. dry with materialdried over sodium sulfate
14. concentrationconcentrated to an oil
15. customThe oil is chromatographed on silica gel (100 mL)