Ethylamine hydrochloride → HCID 18668644, compound

HRID 1059245Notes

Reaction equation

HRID 1059245 reaction equation
[Br:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=O)[CH:5]=[CH:4][CH:3]=1.Cl.[CH2:12]([NH2:14])[CH3:13].Cl.CN(C)CCCN=C=NCC.ON1C2C=CC=CC=2N=N1>C(N(CC)CC)C>[Br:1][C:2]1[N:7]=[C:6]([C:8]([NH:14][CH2:12][CH3:13])=[O:10])[CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 11198Ethylamine hydrochlorideHCID 757711-HydroxybenzotriazoleHCID 5939196-Bromopyridine-2-carboxylic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

Product 1

HCID 18668644HCID 18668644, compoundYield 92.2%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

By the reaction in the same manner as in Example 55-(i) using 6-bromopicolinic acid (3.06 g), ethylamine hydrochloride (2.49 g), triethylamine (6 ml), 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (3.61 g) and 1-hydroxybenzotriazole (2.66 g), the title compound (3.20 g) was obtained as a colorless oil.

Sources & evidence

ORD record
ord-9046539a4ab741e9b8cc330548e4f922
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

Loading…