Hydrochloric Acid → (10H-Pyrazino[2,3-b][1,4]benzothiazin-8-yl)acetamidine hydrochloride

HRID 1059448Notes

Reaction equation

HRID 1059448 reaction equation
[N:1]1[C:10]2[NH:9][C:8]3[CH:11]=[C:12]([CH2:15][C:16]([NH2:18])=[NH:17])[CH:13]=[CH:14][C:7]=3[S:6][C:5]=2[N:4]=[CH:3][CH:2]=1.[ClH:19]>CO.C(OCC)(=O)C>[ClH:19].[N:1]1[C:10]2[NH:9][C:8]3[CH:11]=[C:12]([CH2:15][C:16]([NH2:18])=[NH:17])[CH:13]=[CH:14][C:7]=3[S:6][C:5]=2[N:4]=[CH:3][CH:2]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 18670382(10H-Pyrazino[2,3-b][1,4]benzothiazin-8-yl)acetamidine

Product 1

HCID 18670381(10H-Pyrazino[2,3-b][1,4]benzothiazin-8-yl)acetamidine hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

(10H-Pyrazino[2,3-b][1,4]benzothiazin-8-yl) acetamidine was dissolved in a small amount of methanol and a solution of hydrogen chloride in ethyl acetate was added thereto under ultrasonication. Thus, the title compound was obtained almost quantitatively as the precipitated orange crystals.

Workup

  1. customunder ultrasonication

Sources & evidence

ORD record
ord-6ad375a7622c44c28a0864f6c5081fde
Source dataset
uspto-grants-2003_02
Patent number
US06518423B1

Reaction notes

Loading…