Phenethylamine → 6-(1-Chloroethyl)-5-iodo-4-(2-phenylethylamino)pyrimidine

HRID 1059688Notes

Reaction equation

HRID 1059688 reaction equation
[C:1]1([CH2:7][CH2:8][NH2:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.Cl[C:18]1[C:23]([I:24])=[C:22]([CH:25]([Cl:27])[CH3:26])[N:21]=[CH:20][N:19]=1>C1(C)C=CC=CC=1>[Cl:27][CH:25]([C:22]1[N:21]=[CH:20][N:19]=[C:18]([NH:9][CH2:8][CH2:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:23]=1[I:24])[CH3:26]

Participants

5

Reactant 3

HCID 1001PhenethylamineHCID 8471TriethylamineHCID 154522994-Chloro-6-(1-chloroethyl)-5-iodopyrimidine

Product 1

HCID 154523006-(1-Chloroethyl)-5-iodo-4-(2-phenylethylamino)pyrimidine

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
60 °C

Procedure

In 20 ml of toluene were dissolved 2-phenylethylamine (0.6 g) and triethylamine (0.6 g), then, 4-chloro-6-(1-chloro-ethyl)-5-iodopyrimidine (1.5 g) was added to the solution, and the mixture was heated at about 60° C. for 3 hours while stirring.

Sources & evidence

ORD record
ord-edd44ce9681c4d66bf25a094f3cb537b
Source dataset
uspto-grants-2003_02
Patent number
US06521627B1

Reaction notes

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