反应详情

To a solution of methylamine in methanol (40% w/w, 5 ml) was added 2-chloro-7-(4-methoxypyridin-2-yl)quinoline (140 mg). The mixture was heated in a steel autoclave at 120° C. for 16 hours. After cooling, the solvent was evaporated under reduced pressure. The residue was purified by column chromatography (silica gel 25 g, 5% methanol in dichloromethane). The compound obtained was dissolved in ethyl acetate, and a solution of hydrogen chloride in 1,4-dioxane (4N, 1 ml) was added. The precipitate was collected by filtration and dried to give 7-(4-methoxypyridin-2-yl)-2-methylaminoquinoline dihydrochloride (106 mg).

1. temperatureAfter cooling
2. customthe solvent was evaporated under reduced pressure
3. customThe residue was purified by column chromatography (silica gel 25 g, 5% methanol in dichloromethane)
4. customThe compound obtained
5. filtrationThe precipitate was collected by filtration
6. customdried