Water → HCID 18631011, compound

HRID 1060022Notes

Reaction equation

HRID 1060022 reaction equation
[CH3:1][NH2:2].F[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][N:11]=2)=[CH:6][C:5]=1[N+:18]([O-:20])=[O:19].O>O1CCCC1>[CH3:1][NH:2][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][N:11]=2)=[CH:6][C:5]=1[N+:18]([O-:20])=[O:19]

Participants

5

Reactant 3

HCID 962WaterHCID 6329MethylamineHCID 18667517HCID 18667517, compound

Product 1

HCID 18631011HCID 18631011, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of methylamine in tetrahydrofuran (2M, 11 ml) was added 1-fluoro-4-(4-methoxypyridin-2-yl)-2-nitrobenzene (289 mg). The mixture was stirred at ambient temperature for 2 hours and poured into water. The precipitate was collected by filtration and dried to give 1-methylamino-4-(4-methoxypyridin-2-yl)-2-nitrobenzene (280 mg).

Workup

  1. filtrationThe precipitate was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-a2c13635851f48c99bef068d32f0a0d0
Source dataset
uspto-grants-2003_02
Patent number
US06521643B1

Reaction notes

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