反应详情

温度

150 °C

To a stirred solution of 4-fluorobenzaldehyde (24.1 g) and p-cresol (21 g) in N,N-dimethylformamide (400 ml) was added powdered potassium carbonate (26.8 g) and the reaction mixture was stirred at 150° C. for 7.5 hours. After cooling, the reaction mixture was poured into ice water (1.4 kg). The mixture was extracted with ethyl acetate (1 l), washed with water (1 l×3), brine (1 l), dried over anhydrous magnesium sulfate and concentrated in vacuo to give 4-(4-methylphenoxy)benzaldehyde (40.7 g) as a light yellow oil.

1. temperatureAfter cooling
2. extractionThe mixture was extracted with ethyl acetate (1 l)
3. washwashed with water (1 l×3), brine (1 l)
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated in vacuo