Hydrochloric Acid → HCID 86588735, compound

HRID 1063919Notes

Reaction equation

HRID 1063919 reaction equation
O1CCCCC1[O:7][NH:8][C:9](=[O:37])[CH2:10][C@@:11]1([C:27]2[S:28][C:29]([C:32]3[O:33][CH:34]=[CH:35][CH:36]=3)=[CH:30][CH:31]=2)[S:17](=[O:19])(=[O:18])[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]1.[ClH:38]>CO.C(OCC)(=O)C>[ClH:38].[OH:7][NH:8][C:9](=[O:37])[CH2:10][C@@:11]1([C:27]2[S:28][C:29]([C:32]3[O:33][CH:34]=[CH:35][CH:36]=3)=[CH:30][CH:31]=2)[S:17](=[O:19])(=[O:18])[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 23402038HCID 23402038, compound

Product 1

HCID 86588735HCID 86588735, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of N-(2-tetrahydropyranyloxy)-2-[(S)-7-(5-(2-furyl)-2-thienyl)-4-tert-butoxycarbonyl-1,1-dioxoperhydro-1,4-thiazepin-7-yl]acetamide (160 mg) in methanol (5 ml) was added 4M hydrogen chloride in ethyl acetate (5 ml) at room temperature. After being stirred for 1 hour, the mixture was concentrated in vacuo. The resulting residue was triturated with diethyl ether to afford N-hydroxy-2-[(S)-7-(5-(2-furyl)-2-thienyl)-1,1-dioxoperhydro-1,4-thiazepin-7-yl]acetamide hydrochloride (75 mg) as a powder.

Workup

  1. concentrationthe mixture was concentrated in vacuo
  2. customThe resulting residue was triturated with diethyl ether

Sources & evidence

ORD record
ord-68c4b755c3e4460f9c389e0787b9bef5
Source dataset
uspto-grants-2005_11
Patent number
US06967197B2

Reaction notes

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