Acetic Acid → HCID 4532937, compound

HRID 1063994Notes

Reaction equation

HRID 1063994 reaction equation
[NH:1]1[CH2:5][C:4](=[O:6])[NH:3][C:2]1=[O:7].C(O)(=O)C.[N:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH:18]=O)[CH:13]=1.N1CCCCC1>C(O)(C)C.C1(C)C=CC=CC=1>[N:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH:18]=[C:5]2[NH:1][C:2](=[O:7])[NH:3][C:4]2=[O:6])[CH:13]=1

Participants

7

Reactant 4

HCID 176Acetic AcidHCID 8082PiperidineHCID 10006HydantoinHCID 103713-Pyridinecarboxaldehyde

Product 1

HCID 4532937HCID 4532937, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 3776IsopropanolSolvent

Procedure

0.1 mol of imidazolidine-2,4-dione, 3 ml of glacial acetic acid, 0.12 mol of pyridine-3-carbaldehyde and 30 ml of toluene were introduced into a round-bottomed flask. 5 ml of piperidine were also added to this mixture. The combination was heated at reflux for 17 h. After cooling, isopropanol was added. The precipitate obtained was filtered off and washed with isopropanol. The yield of 5-(3-pyridylmethylene)imidazolidine-2,4-dione was 85%.

Workup

  1. temperatureThe combination was heated
  2. temperatureat reflux for 17 h
  3. temperatureAfter cooling
  4. customThe precipitate obtained
  5. filtrationwas filtered off
  6. washwashed with isopropanol

Sources & evidence

ORD record
ord-993c7abbb50d45119cf0ab1effd8b9df
Source dataset
uspto-grants-2005_11
Patent number
US06967253B2

Reaction notes

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