1-Methylpiperazine → HCID 135455994, compound

HRID 1066028Notes

Reaction equation

HRID 1066028 reaction equation
Cl[S:2]([C:5]1[CH:6]=[C:7]([C:14]2[NH:15][C:16](=[O:27])[C:17]3[N:22]([CH3:23])[N:21]=[C:20]([CH2:24][CH2:25][CH3:26])[C:18]=3[N:19]=2)[C:8]2[O:12][CH2:11][CH2:10][C:9]=2[CH:13]=1)(=[O:4])=[O:3].[CH3:28][N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>C1COCC1>[CH3:28][N:29]1[CH2:34][CH2:33][N:32]([S:2]([C:5]2[CH:6]=[C:7]([C:14]3[NH:15][C:16](=[O:27])[C:17]4[N:22]([CH3:23])[N:21]=[C:20]([CH2:24][CH2:25][CH3:26])[C:18]=4[N:19]=3)[C:8]3[O:12][CH2:11][CH2:10][C:9]=3[CH:13]=2)(=[O:4])=[O:3])[CH2:31][CH2:30]1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 135515526HCID 135515526, compound

Product 1

HCID 135455994HCID 135455994, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Compound 6a (1.25 g, 0.003 mole) was dissolved in THF (10 ml) and added to a solution of 1-methylpiperazine (1 ml) in THF (10 ml). The resulting mixture was stirred at room temperature for 1 h. The THF was then removed in vacuo, and the residue was treated with cold water (50 ml). The resulting white precipitate was filtered under suction, washed with water (2×10 ml), drained and recrystallized from 90% ethanol, thereby yielding 7a.

Workup

  1. customThe THF was then removed in vacuo
  2. additionthe residue was treated with cold water (50 ml)
  3. filtrationThe resulting white precipitate was filtered under suction
  4. washwashed with water (2×10 ml)
  5. customrecrystallized from 90% ethanol

Sources & evidence

ORD record
ord-247119f4108d455a93738ec3876d0f59
Source dataset
uspto-grants-2001_06
Patent number
US06242444B1

Reaction notes

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