反应详情

To a solution of sodium (1.3 g, 52 mmol) in ethanol (50 mL) was added diethyl malonate (8.8 g 55 mmol) followed by 6,9-dichloro-2-methoxyacridine (9.68 g, 35 mmol) and toluene (5 mL). The mixture was heated to reflux for 24 h, diluted with aqueous potassium carbonate, extracted with ethyl acetate, dried, and concentrated in vacuo to give solid which was purified by flash column chromatography (silica gel, 5-12% methanol:dichloromethane) to give the title compound. MS(ES) m/e 402.2 (M+H)+.

1. temperatureThe mixture was heated
2. temperatureto reflux for 24 h
3. extractionextracted with ethyl acetate
4. customdried
5. concentrationconcentrated in vacuo
6. customto give solid which
7. customwas purified by flash column chromatography (silica gel, 5-12% methanol:dichloromethane)