Oxalyl chloride → Thiophene-2-sulfonyl isocyanate

HRID 1066358Notes

Reaction equation

HRID 1066358 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[S:6]([NH-:9])(=[O:8])=[O:7].C(Cl)(=O)[C:11](Cl)=[O:12]>ClCCCl>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[S:6]([N:9]=[C:11]=[O:12])(=[O:8])=[O:7]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 86585375HCID 86585375, compound

Product 1

HCID 12875192Thiophene-2-sulfonyl isocyanate

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

A mixture of 2-thiophenesulfonylamide (1.5 g) and oxalyl chloride (6 mL) in 10 mL of 1,2-dichloroethane was refluxed for 14 h. The solvent was removed under vacuum and the crude used as is for the next step.

Workup

  1. temperaturewas refluxed for 14 h
  2. customThe solvent was removed under vacuum

Sources & evidence

ORD record
ord-c87843ceab0f4afe83f985e1c0d6e408
Source dataset
uspto-grants-2001_06
Patent number
US06242493B1

Reaction notes

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