Trifluoroacetic acid → HCID 21198710, compound

HRID 1066367Notes

Reaction equation

HRID 1066367 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10]([C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1)=O.C([SiH](CC)CC)C.C(O)(C(F)(F)F)=O>C(Cl)(Cl)Cl>[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH2:10][C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 21198682HCID 21198682, compound

Product 1

HCID 21198710HCID 21198710, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
50 °C

Procedure

To the methanone of Step 1 (14.0 g) and triethylsilane (15 mL) in 15 mL of CHCl3 was added TFA and was heated to 50° C. overnight. The solution was cooled and quenched with NaOH (2N) to provide the title compound in 82% yield.

Workup

  1. temperatureThe solution was cooled
  2. customquenched with NaOH (2N)

Sources & evidence

ORD record
ord-f73f2178f3384c61bb5c4b27705a336f
Source dataset
uspto-grants-2001_06
Patent number
US06242493B1

Reaction notes

Loading…