Succinic anhydride → 4-oxo-4-[4-(pyridin-2-yl)piperazin-1-yl]butanoic acid

HRID 1066561Notes

Reaction equation

HRID 1066561 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[C:13]1(=[O:19])[O:18][C:16](=[O:17])[CH2:15][CH2:14]1>CN(C)C=O>[O:19]=[C:13]([N:10]1[CH2:9][CH2:8][N:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH2:12][CH2:11]1)[CH2:14][CH2:15][C:16]([OH:18])=[O:17]

Participants

4

Reactant 2

HCID 7922Succinic anhydrideHCID 944591-(2-Pyridyl)piperazine

Product 1

HCID 7357834-oxo-4-[4-(pyridin-2-yl)piperazin-1-yl]butanoic acidYield 64.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 1-(2-pyridyl)piperazine (1.63 g) and succinic anhydride (1.1 g) in dimethylf ormamide (5 ml) was stirred for 24 hours at room temperature. The reaction mixture was reduced under reduced pressure and the concentrate was recrystallized from ethanol to give the titled compound (1.7 g) as a pale yellow crystal.

Workup

  1. customthe concentrate was recrystallized from ethanol

Sources & evidence

ORD record
ord-6b30657b17714c3595421695a26eb80e
Source dataset
uspto-grants-2001_06
Patent number
US06242600B1

Reaction notes

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