Lithium Hydroxide → HCID 21196068, compound

HRID 1066802Notes

Reaction equation

HRID 1066802 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([O:6][CH2:7][C:8]2[N:9]([CH3:23])[C:10]3[C:15]([C:16]=2[CH2:17][CH2:18][C:19]([O:21]C)=[O:20])=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:4][CH:3]=1.[OH-].[Li+]>O1CCCC1>[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([O:6][CH2:7][C:8]2[N:9]([CH3:23])[C:10]3[C:15]([C:16]=2[CH2:17][CH2:18][C:19]([OH:21])=[O:20])=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 21195973HCID 21195973, compound

Product 1

HCID 21196068HCID 21196068, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Under a nitrogen atmosphere in a round bottom flask 2-[(4-chlorophenoxy)methyl]-1-methyl-3-[2-(methoxycarbonyl)ethyl]-1H-indole (0.275 g, 0.771 mmol) was dissolved in 8 ml of dry tetrahydrofuran. To this solution was added 4.0 ml of a 2.0 N lithium hydroxide solution. The reaction mixture was stirred at room temperature overnight. The progress of the reaction was monitored by thin layer chromatography.

Sources & evidence

ORD record
ord-7421cf4781d84dd5b283e5aa5fe10e11
Source dataset
uspto-grants-2001_06
Patent number
US06245761B1

Reaction notes

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