1H-1,2,4-Triazole → HCID 10058763, compound

HRID 1067379Notes

Reaction equation

HRID 1067379 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([CH:8]=1)[NH2:7].[NH:12]1[CH:16]=[N:15][CH:14]=[N:13]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[N:12]1([C:2]2[CH:3]=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([CH:8]=2)[NH2:7])[CH:16]=[N:15][CH:14]=[N:13]1

Participants

5

Reactant 3

HCID 92571H-1,2,4-TriazoleHCID 11430Potassium CarbonateHCID 742185-Chloro-2-nitroaniline

Product 1

HCID 10058763HCID 10058763, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
130 °C

Procedure

A 10.0 g portion of 5-chloro-2-nitroaniline, 8.0 g of 1,2,4-triazole and 16.0 g of potassium carbonate were suspended in 50 ml of DMF and stirred for 5hours while heating at 130° C. The reaction solution was poured into ice water, and the thus precipitated crystals were collected by filtration and washed with purified water. By washing the crystals with methanol, 10.0 g (84% in yield) of the title compound was obtained. Its physical property values are shown below.

Workup

  1. filtrationthe thus precipitated crystals were collected by filtration
  2. washwashed with purified water
  3. washBy washing the crystals

Sources & evidence

ORD record
ord-95ae0694b07a44b1ab9bbc830c6a6c89
Source dataset
uspto-grants-2001_06
Patent number
US06248768B1

Reaction notes

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