反应详情

0.86 g of N-(6-chloroimidazo[1,2-b]pyridazine-2-carbonyl)glycine ethyl ester was suspended in 30 ml of ethyl acetate; 1.2 g of N-chlorosuccinimide was added, followed by thermal refluxing for 20 hours. After cooling, 30 ml of tetrahydrofuran was added; the mixture was washed with an aqueous solution of sodium thiosulfate and saline and dried with magnesium sulfate. The dry product was concentrated under reduced pressure; ethyl ether was added to the residue; the crystal precipitated was collected by filtration, washed with ethyl ether and dried to yield 0.552 g of the title compound.

1. customrefluxing for 20 hours
2. temperatureAfter cooling
3. washthe mixture was washed with an aqueous solution of sodium thiosulfate and saline
4. dry with materialdried with magnesium sulfate
5. concentrationThe dry product was concentrated under reduced pressure
6. additionethyl ether was added to the residue
7. customthe crystal precipitated
8. filtrationwas collected by filtration
9. washwashed with ethyl ether
10. customdried