Hydrochloric Acid → HCID 21193249, compound

HRID 1068476Notes

Reaction equation

HRID 1068476 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:18](=[O:26])[C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH3:25])[CH:20]=2)([C:14]([O:16][CH3:17])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:27]>C(OCC)(=O)C>[ClH:27].[CH3:25][C:21]1[CH:20]=[C:19]([CH:24]=[CH:23][CH:22]=1)[C:18]([C:11]1([C:14]([O:16][CH3:17])=[O:15])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:26]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54052971HCID 54052971, compound

Product 1

HCID 21193249HCID 21193249, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of methyl N-tert-butoxycarbonyl-4-(3-methyl-benzoyl)piperidine-4-carboxylate (77 mg) in ethyl acetate (10 mL) at 0° C. was saturated with hydrogen chloride gas. The resultant solution was stirred at 0° C. for 2.5 h. The product solution was concentrated under vacuum to provide the title compound.

Workup

  1. customat 0° C.
  2. concentrationThe product solution was concentrated under vacuum

Sources & evidence

ORD record
ord-491de4bf7fb2437d90b018f2b65a6bc9
Source dataset
uspto-grants-2001_06
Patent number
US06248756B1

Reaction notes

Loading…