4-Methylmorpholine → HCID 10139639, compound

HRID 1069021Notes

Reaction equation

HRID 1069021 reaction equation
[CH:1]([S:4][S:5][CH2:6][C:7]([OH:9])=O)([CH3:3])[CH3:2].ClC(OCC(C)C)=O.CN1CCOCC1.[Br:25][C:26]1[CH:27]=[C:28]([NH:32][C:33]2[C:42]3[C:37](=[CH:38][CH:39]=[C:40]([NH2:43])[CH:41]=3)[N:36]=[CH:35][N:34]=2)[CH:29]=[CH:30][CH:31]=1>O1CCCC1.C(Cl)Cl.CO>[Br:25][C:26]1[CH:27]=[C:28]([NH:32][C:33]2[C:42]3[C:37](=[CH:38][CH:39]=[C:40]([NH:43][C:7](=[O:9])[CH2:6][S:5][S:4][CH:1]([CH3:2])[CH3:3])[CH:41]=3)[N:36]=[CH:35][N:34]=2)[CH:29]=[CH:30][CH:31]=1

Participants

8

Reactant 4

HCID 79724-MethylmorpholineHCID 62365Isobutyl chloroformateHCID 5328042N4-(3-Bromophenyl)quinazoline-4,6-diamineHCID 54485667HCID 54485667, compound

Product 1

HCID 10139639HCID 10139639, compoundYield 1%

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 6344DichloromethaneSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

A solution of 1.4 grams of disulfide acid from Example 78 in 30 mL of tetrahydrofuran was cooled in an ice bath. A 1.1 mL portion of isobutyl chloroformate followed by a 0.9 mL portion of N-methylmorpholine were added. After stirring for 5 minutes at 0° C., 0.66 grams of N-(3-bromophenyl)-4,6-quinazolindiamine was added. The mixture was stirred for 3 hours at 0° C. and then allowed to warm to room temperature. The reaction was quenched with water and the tetrahydrofuran was evaporated under vacuum. Addition of methylene chloride followed by washing the methylene chloride layer with water and evaporation of the solvent gave a crude product. Silica gel chromatography with methanol in methylene chloride gave 0.01 grams of product.

Workup

  1. additionwere added
  2. stirringThe mixture was stirred for 3 hours at 0° C.
  3. temperatureto warm to room temperature
  4. customThe reaction was quenched with water
  5. customthe tetrahydrofuran was evaporated under vacuum
  6. additionAddition of methylene chloride
  7. washby washing the methylene chloride layer
  8. customwith water and evaporation of the solvent
  9. customgave a crude product

Sources & evidence

ORD record
ord-2c6aa8b00187466599a9f12258fc9ef8
Source dataset
uspto-grants-2001_06
Patent number
US06251912B1

Reaction notes

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