Imidazole → HCID 77750365, compound

HRID 1069033Notes

Reaction equation

HRID 1069033 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[CH2:11][N:12]([CH:35]1[CH2:37][CH:36]1[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)[C:13]1[C:14]2[N:25]=[N:24][N:23]([CH:26]3[CH2:30][CH:29]([CH2:31][OH:32])[CH:28]([OH:33])[CH:27]3[OH:34])[C:15]=2[N:16]=[C:17]([S:19][CH2:20][CH2:21][CH3:22])[N:18]=1.N1C=CN=C1.[C:49]([Si:53](Cl)([C:60]1[CH:65]=[CH:64][CH:63]=[CH:62][CH:61]=1)[C:54]1[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=1)([CH3:52])([CH3:51])[CH3:50].O>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[CH2:11][N:12]([CH:35]1[CH2:37][CH:36]1[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)[C:13]1[C:14]2[N:25]=[N:24][N:23]([CH:26]3[CH:27]([OH:34])[CH:28]([OH:33])[CH:29]([CH2:31][O:32][Si:53]([C:49]([CH3:52])([CH3:51])[CH3:50])([C:60]4[CH:61]=[CH:62][CH:63]=[CH:64][CH:65]=4)[C:54]4[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=4)[CH2:30]3)[C:15]=2[N:16]=[C:17]([S:19][CH2:20][CH2:21][CH3:22])[N:18]=1

Participants

6

Reactant 4

HCID 795ImidazoleHCID 962WaterHCID 94078tert-ButyldiphenylchlorosilaneHCID 77750311HCID 77750311, compound

Product 1

HCID 77750365HCID 77750365, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of the product of step (a) (1.11 g), imidazole (417 mg) and tert-butylchorodiphenylsilane (0.75 ml) in dry DMF (4 ml) was stirred for 18 hours. Water was added and the mixture was extracted with ethyl acetate. The organic extracts were dried, concentrated and purified (SiO2, petrol:acetone 3:1 as eluant) to give the subtitle compound (1.16 g).

Workup

  1. extractionthe mixture was extracted with ethyl acetate
  2. customThe organic extracts were dried
  3. concentrationconcentrated
  4. custompurified (SiO2, petrol:acetone 3:1 as eluant)

Sources & evidence

ORD record
ord-853cb5cf9d3e46548a679887a6d6566c
Source dataset
uspto-grants-2001_06
Patent number
US06251910B1

Reaction notes

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