反应详情

To a solution of 5.00 g of 3-hydroxymyristic acid in 50 ml of DMF were added at room temperature 2.85 ml of triethylamine and 2.43 ml of benzyl bromide. The reaction mixture was stirred at room temperature overnight. The solvent was removed in vacuo, ethyl acetate and water were added to the residue, and the organic layer was separated, washed twice with water and dried over anhydrous sodium sulfate. After the solvent was removed in vacuo, the crude product was purified by a silica gel column chromatography to afford 3.69 g of benzyl 3-hydroxymyristate (Intermediate 2).

1. customThe solvent was removed in vacuo, ethyl acetate and water
2. additionwere added to the residue
3. customthe organic layer was separated
4. washwashed twice with water
5. dry with materialdried over anhydrous sodium sulfate
6. customAfter the solvent was removed in vacuo
7. customthe crude product was purified by a silica gel column chromatography