反应详情

Hydrazine monohydrate (0.661 ml) was added to a solution of N-[3-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxy]phthalimide (3.00 g) in ethanol (25 ml)-tetrahydrofuran (25 ml) and heated under reflux for 3 hours. The reaction mixture was cooled to room temperature, an aqueous solution of potassium carbonate was added and extracted with ethyl acetate. The ethyl acetate layer was washed with an aqueous saturated solution of sodium chloride, dried (MgSO4) and concentrated. The remaining crystals were recrystallized from ethyl acetate-hexane to obtain 3-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxyamine (2.04 g, yield 97%) as pale-yellow crystals. m.p. 81-82° C.

1. temperatureheated
2. temperatureunder reflux for 3 hours
3. extractionextracted with ethyl acetate
4. washThe ethyl acetate layer was washed with an aqueous saturated solution of sodium chloride
5. dry with materialdried (MgSO4)
6. concentrationconcentrated
7. customThe remaining crystals were recrystallized from ethyl acetate-hexane