反应详情

5 g (˜25 mmol) 2-(3,4-epoxybutyl)-isoindolin-1,3-dione, 7.5 g (30 mmol) benzhydrylpiperazine and 3.5 g (25 mmol) potassium carbonate are stirred in DMF for 6 hours 80° C. After cooling, the reaction mixture is filtered and concentrated under vacuum. The residue is taken up in 300 ml acetic acid ethyl ester and washed three times each with 20 ml water. The organic phase is dried over sodium sulfate and the solvent is removed under vacuum. The residue is chromatographically purified over silica gel with CHCl3/CH3OH.

1. temperatureAfter cooling
2. filtrationthe reaction mixture is filtered
3. concentrationconcentrated under vacuum
4. washwashed three times each with 20 ml water
5. dry with materialThe organic phase is dried over sodium sulfate
6. customthe solvent is removed under vacuum
7. customThe residue is chromatographically purified over silica gel with CHCl3/CH3OH