反应详情

To a suspension of 3,3-diphenylpropionic acid (14 mg, 0.06 mmol) and HOBt (9 mg, 0.07 mmol) in ethyl acetate (1.5 mL) a solution of EDC (12 mg, 0.06 mmol) in ethyl acetate (0.5 mL) was added. The resulting mixture was shaken for 20 min at room temperature and then 4,5,6,7-tetrahydroimidazo[4,5-c]pyridine dihydrochloride (12 mg, 0.06 mmol) and triethylamine (0.02 mL) were added. After shaking for 16 h the mixture was washed with brine (2×2 mL), and the organic phase was concentrated. 12 mg (60%) of the title amide was obtained.

1. additionwas added
2. stirringAfter shaking for 16 h the mixture
3. washwas washed with brine (2×2 mL)
4. concentrationthe organic phase was concentrated